C is not in E, though C is in E.
It mainly has to do with frequencies. You should know that when you double a frequency, you get an octave. Now, if you double that, you get a pitch a fifth above the octave. Double that, and you get an octave. Double it once more, and it's a 4th. These perfect intervals are called harmonics. The original pitch is called the fundamental. After that, the octave is 2nd harmonic, the 3rd harmonic (5th),4th harmonic (2nd octave), and the 5th harmonic (4th). Got it?
?