Any piece in particular?
If the piece is not for piano (for voices, or four instruments), I suggest you rewrite it in two staves. If the piece is originally for piano, and it is in 4 staves because it would be far too complex to put it all in two staves, then it is difficult to give advice that will work when your question is so vague. In general, the distribution of voices amongst the hands should be obvious: whatever is the most comfortable position.
Best wishes,
Bernhard.