Any piece with excessive double or triple chords playing non stop in one hand will kill your hand. Like..... ammm.. for instance Liszt's Feux-Follets (Will-o'-the-Wisp), from the Transcendentale etude, no 5.
Also any chords/arpeggios which stretch the hand arkwardly, you find that in Rachmaninov many times and Scriabin and of course many others.
To practice in uncomfortable grounds it is many times a matter of neglecting one note or so to make the practice easier. Cycle through different variations of missing out notes, so then when you play them all together your natural method reveals itself. This lets you spend much more time on tough sections than you otherwise physically could.
For instance, overpracticing the tremolo Ondine from Ravel's Gaspard de la Nuit can cause you pain. You have to practice with very light fingers, if they are a fraction too heavy, then within a few minutes of practice your hands will start hurting. Fortunately you are required to play in the ppp range, but if where to say ff, then by no means would we ever start practicing it at that volume. We would learn to play it very gently then increase the volume, this would apply for any difficult section of music. I wouldnt play it with the volume expression, everything else is fine, volume is best controlled once you master the actual movement of the notes and these can be practiced in very quiet ranges which will extend your endurance and time spent practicing and minimise the adverse effect uncomfrtable sections may have on your body.
Also to practice the opening tremolo we might choose to miss out one or two of the notes of the 3 notes chord in the RH. And then add one at a time and see the effect adding notes has on your hand and question yourself how to control it. All difficult sections can be reduced to a single note, and that everyone can play. It is a matter of adding a little at time, in a smart way which reveals this natural way to play. It is different for everyone, so i couldnt say how to do it.