I think Bob was asking about a Pentatonic scale, where you could either play:
123 123 123 123 for two octaves
or
1234 1234 1234 for the same.
I'd say it depends on the scale. If, and where, there are any black keys. I've never practised it so i don't know really, and i can't think of a piece either right now...
If it's only white keys, 123 123 and so on seems a little "cramped" in my view. 1234 1234 would flow better i think.