Yes, it can be done, no bleeding fingers or drama whatsoever, including in the Brahms Paganini variations.
I am an advanced amateur, played that stuff since my teens, (now 70), (struggled trying octave glissandi) but now have a Hamburg Steinway Model M, properly regulated, and it's easy.
However, recently heard the great Paul Lewis live in Sydney doing the Waldstein, sans glissando, and I asked him why? (Whilst having his CD issue of the 32 autographed -- Fantastic, and I include Arrau etc live!) He rightly said that he was going for a special "aurora" (awaking of sunrise) effect that required a pianissimo octave, which he did brilliantly both hands. He said he tried glissando on pianos of Beethoven's day with their light actions (Erard) and that was OK, but on a modern Steinway the effect came across too loud.
Makes eminent sense to me!
So how about the opening bar of Opus 2 no. 3 ? Should one cheat? I guess the real answer is if you ain't got the technique, you ain't ready to play it!
Personally, my favorite is opus 7, which i think I play quite well and at speed. But stage fright and memory lapses prevented me from progressing, way back....................
Hope this throws some light on a fascinating topic.
Nick Marshall
Sydney, Australia