Basically i wouldn't work on a whole piece H.S.. If you encounter a passage that is very difficult it sure can be helpful to practice H.S. . From the score ( i never played this particular prelude yet but a few others) i suggest you concentrate on a few bars, or maybe page one first to get the rythmic figure right. Practicing slowly(even super slow) is a good approach but be sure the section is not to long. In the poco meno mosso part it could be wise to practice left hand seperate. To me it looks that you need some decent pedaling in this part to hold the half notes and not produce a blurry sound. Please post a recording if possible, once you get into it.
Regards